File this under "We’ve never seen these levels of CO2 and warming since 50 million years ago.”

Not anything as severe as the Permian nor K-T extinction due to very extensive volcanism (Dr. Gerta Keller), but certainly there were minor, less severe extinctions accompanied with volcanoes and flood basalts. Remember that the oceans demonstrate far greater seismic activity than continental activity.

Quaternary extinction events - 640,000, 74,000, and 13,000 years ago. Cause not definite. May include climate changes, massive volcanic eruptions (Keller)

Neogene Pliocene–Pleist ocene boundary extinction — 2 Ma. Possible causes include a supernova or the Eltanin impact (which would trigger volcanism).

Middle Miocene disruption - 14.5 Ma. Climate change due to change of ocean circulation patterns. Milankovitch cycles may have also contributed. (Note the reference to Milankovitch cycles, affecting tectonic plate movement).

Eocene–Oligocen e extinction event - 33.9 Ma. Multiple causes including global cooling, polar glaciation, falling sea levels, and the Popigai impactor (again, the proximate cause of volcanism).